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Alternatives to drugs made with pregnant maresurine, View fundforhorsess profile on Instagram, View tuesdayshorses profile on WordPress.org, http://www.health.harvard.edu/newsletters/Harvard_Womens_Health_Watch/2011/September/bioidentical-hormones-help-or-hype, https://tuesdayshorse.wordpress.com/2017/05/30/report-premarin-ads-on-behalf-of-women-and-horses/, https://store.cabecahealth.com/products/julva-dr-annas-cream-for-delicate-feminine-parts?variant=29958880899, https://www.k-y.com/product/k-y-liquibeads-vaginal-moisturizer-6-ea-067981160468, http://femininehealthreviews.com/smoky-mountain-naturals-progesto-life-full-review-does-it-work/, https://smokymountainnaturals.com/products/paraben-free-estro-life-cream, http://boricplan.com/nutrablast-boric-life-full-review-does-it-work/, https://vmagicnow.com/products/vmagic-intimate-skin-cream?variant=16308526343, https://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=vaginal+dryness&rh=i%3Aaps%2Ck%3Avaginal+dryness, To learn more see our Premstoppers campaign on our website, Saving the Nokota horses: Linton rancher running out of time, land andmoney, Wild horse nonprofit acquires 3,335 acres of Bently Pine Nutland, New DNA analysis reveals untold story of horses inAmerica, Phillys horse drawn carriages could goelectric, Biden fulfilling Trumps cruel policy on wildhorses, Number of injured animals could rise following Appomattox horseshootings. Because these products prevent large amounts of estrogen from passing through the rest of the body, as a rule they are considered safer than other forms of HRT and just as importantly do not contain CEEs like Premarin cream does. It has been found that melatonin and some of its analogs promote sleep. weight loss. Others are thought to relieve stress and anxiety to help with menopausal mood swings, or have mild anti-inflammatory action. Some of these drugs have been approved by the FDA because data collected from trials has proven their effectiveness in relieving menopausal symptoms and reducing the risk of osteoporosis. (LogOut/ However, this is not an exhaustive list. The exact mechanism of action for many of the non-prescription alternatives is unknown, however several theories have suggested they act as antagonists on estrogen receptors, or alternatively as selective estrogen receptor modifiers (SERMs). In 2001, the US Supreme Court ruled that pharmacies could indeed market compounded products that were unregulated by the FDA. The terminology is confusing and the FDA considers BHRT to be a marketing term. The horses are blessed to have such champions in their corner, like you and Jane. In several randomized controlled trials using soy and placebo, less than half of these trials (45%) showed a significant improvement in symptoms compared to placebo. Genistein, an isoflavone found in low concentrations in soybeans and elevated amounts in certain soy-derived food has attracted scientific interest for its possible benefits in cancer and heart disease prevention as well as reducing menopausal symptoms. It is believed to help influence prostaglandin synthesis and help moderate menopausal symptoms. As with prescription creams, they are intended to relieve common vaginal symptoms of menopause. Some studies claim that kava may be an effective option for treating anxiety, stress, and restlessness, for menopausal mood swings as well as sleeping problems but the data is conflicting. Heat can cause the patch to release the estrogen too quickly so it is important not to expose them to high heat or direct sunlight (e.g. The lack of distinction between FDA-approved bioidentical hormones (often referred to as synthetics) and compounded bioidentical hormones has resulted in considerable misunderstanding regarding exactly what BHRT is. Everyday when I take Metformin I usually have constipation and the top of my feet are swollen up. A few examples of the different kinds of OTC (over the counter) alternatives follow. One such trial compared the effectiveness of; (1) shallow acupuncture; (2) electro-acupuncture and; (3) oral estrogen. There were no adverse effects or safety concerns with short term administration although long-term randomized studies are lacking. Currently the vast majority of FDA-approved HRT prescription drugs are synthetic bioidenticals often referred to as Synthetics (i.e. My doctor is a post-menopausal woman and though I personally do not have any issues needing any form of HRT, the first thing she pushed at the very first visit was Premarin. Where positive effects were shown, the soy reduced hot flashes by 9 to 40 percent in some trials, but others showed no difference compared with placebo. Doctors are getting pretty free and easy about off-label prescribing this dangerous drug (I say dangerous having read not only the package insert approved/required by the FDA but also some of the research actually available to the public many medical websites are available only by expensive subscription and then only to licensed medical practitioners). Take Action to Help End the Misery of PMU Horses. There are tens of millions of compounded hormone therapy prescriptions a year filled at community and compounding pharmacies for at least 2 billion dollars definitely a money-making business. Please consult your doctor for more information on these FDA-approved prescription alternatives to Premarin vaginal cream. Metformin also known by its brand names Glucophage Riomet and Fortamet is a medication used to treat type 2 diabetes. As a word of caution, in some individuals adverse effects can occur with acupuncture. It has been one of the best selling drugs in America. Using OTC products or eating natural foods that contain these compounds (e.g. We encourage you to go online to further acquaint yourself with the effectiveness and safety of these compounds. Dont waste your money. cancer and stroke). Avoid high fat dairy products and meats and supplement these items with healthy fats such as olive oil, nuts, seeds and lean cuts of meat or fish. A very popular medicine, called Premarin, is actually made from horse urine of pregnant mares. Phytoestrogens are naturally occurring substances found in fruits, vegetables, and whole grains such as soybeans, alfalfa sprouts, and oilseeds (such as flaxseed). Lifestyle Solutions: Common sense solutions that include dressing in layers, lowering room temperatures, consuming cool drinks, and cutting down on alcohol, caffeine and spicy foods. Your guess is as good as mine. A list of some of the prescription alternatives to Premarin cream in their various forms is shown below. Clonadine acts in the brain to decrease blood pressure. Ive been trying to research, but this is an enormous help! Premarin works great in female horses, just as Chevy parts work great in Chevys. It also works by decreasing the amount of glucose made by the liver and decreasing the absorption of glucose from the intestine. They don't smell like urine or fish but they are very bitter. No matter what, it is important to separate fact from fiction and be astutely aware of the consequences of clinically unproven medications. Be sure to read the ingredient labels prior to use. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain cells. Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. Metformin is called "exercise in a tablet" by some vets, and may be prescribed if a horse cannot exercise due to laminitis, or if insulin levels are very high. Gabapentin is a drug used to control epileptic seizures, shingles and restless leg syndrome that in some studies has shown to be as effective as estrogen in treating symptoms of menopause. There is also convincing evidence that some prescription drugs which are not licensed for treating menopausal symptoms do in fact alleviate hot flashes and night sweats. Give Up Smoking: If you smoke, giving up will help reduce hot flushes and your risk of developing serious health conditions, such as heart disease, stroke and cancer. Reflexology is generally relaxing and may be an effective way to alleviate stress. Many women report that the herb works well but it isnt effective for everyone. Additionally, a simple search for vaginal dryness on Amazon.com will give you an idea of just how many and what kinds of OTC products are available. Blood and saliva tests to measure a womans hormones is only a snapshot in time and are not reflective of serum (blood) hormone levels which can fluctuate from hour to hour. If it is almost time for your next dose skip the missed dose and take your next dose at the regular time. Covaryx, Essian, Estratest, Menogen, Syntest D.S., Syntest H.S. We encourage you to go online to further acquaint yourself with the effectiveness and safety of these compounds. Whats important however is that these drugs carry with them the same risks and warnings associated with drugs derived from conjugate estrogen estrogens, whether that be estrogen alone or combined with progestin. A few examples of the different kinds of OTC (over the counter) alternatives follow. What if I have more questions about Metformin? However, it is important to take the correct dosage if too high, there may be adverse side effects (e.g. Dong Quai finds its roots in traditional Chinese medicine. As always, it is important to work with your physician to make an educated decision on what type of HRT would best suit your needs while limiting your risks. Aging and menopause are normal reactions to growing older. P.O. Survey says . A small randomized study of women aged 45-60 experiencing vasomotor symptoms who were administered either reflexology or non-specific foot massage showed there was a reduction in both groups but no significance between the two groups. Plasma metformin concentration was determined via high-pressure liquid chromatography. One side effect of Metformin is weakness. In pre- and postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. For that reason it is often only used in very serious laminitis bouts or where management changes have failed. Researchers reported that daily treatment with St. Johns wort was more effective than placebo treatment for the most common physical and behavioral symptoms associated with PMS. Several clinical studies have shown that acupuncture can reduce symptoms of menopause. Several placebo-controlled studies that evaluated the effectiveness of red clover in reducing hot flashes showed a modest reduction in frequency in women administered various amounts of red clover compared to those receiving placebo. Many health insurance companies dont cover the cost of these compounded hormone therapies. It is generally safe and well-tolerated with the most common side . Not only will this help alleviate symptoms but the benefits will ensure that you remain healthy now and in the future. It is created by eHealthMe based on reports of 395,495 people who have side . These are just a handful of examples of probably hundreds out there on the market. For example; cardiac tamponade (fluid buildup in the pericardium that compresses the heart); pneumothorax (collapsed lung) and; hepatitis. That's where the name is derived from: PRE gnant MA res' ur IN e = Premarin. Osphena carries with it risky side effects; stimulation of the lining of the uterus that can lead to uterine cancer, increased risk of blood clots, hot flashes and drug interactions. A potential confounder in most hot flash trials is the placebo response rate, which in many studies has been reported as between 18 and 40 percent. There have been cases of endometrial (uterine) cancer noted among some users of bioidenticals. Additionally, significant improvements were seen in general, emotional and mental fatigue as well as the occurrence of clinical depression (as expected). Moreover, long term treatment with soy has shown a small risk of endometrial hyperplasia (growth of abnormal cells/precancerous neoplasms) that can lead to endometrial cancer in a small percentage of women. No, penicillin is not made from horse urine. The name Premarin was coined from pregnant mare urine, from which the estrogen complex was isolated. Many health insurance companies dont cover the cost of these compounded hormone therapies. Thank you Alexis. Since these forms are absorbed through the skin directly into the bloodstream, its important to prevent people from touching any of these as they will inadvertently get a dose of estrogen as well. Rubber collection bags are affixed between their legs causing painful lesions and infections. How? Ginseng may come to the rescue on this front, possibly supporting healthy sleep cycles by aiding relaxation. decreased appetite. Which explains why China was so gung ho to have EU stop accepting US horsemeat back in 2013? The difference between the two is the accuracy of preparation. 2,654. Although many women believe that these compounded bioidentical therapies are more natural and safer, since they are not FDA approved, they are not tracked or monitored the same way. Alternatives to drugs made with pregnant mare's urine. For those women who are overweight, weight loss can also help. Why do pharmaceutical giant Pfizer persist with the Premarin line of drugs? Metformin is a human drug prescribed for the treatment of type II diabetes mellitus. This has been one of the most prescribed drugs in the United States. Serotonin is one of the chemical messengers (neurotransmitters) that carry signals between brain cells. In other words no prescription drugs used to treat menopausal symptoms, other than the Premarin family, contain pregnant mares urine (this does not include China or other locations outside of the FDAs jurisdiction). Can I take Metformin if I am breastfeeding? Prempro, Premphase). Several placebo-controlled studies that evaluated the effectiveness of red clover in reducing hot flashes showed a modest reduction in frequency in women administered various amounts of red clover compared to those receiving placebo. It is generally safe and well-tolerated with the most common side effects being gastrointestinal upset. This plant was fed to goats to improve milk production. There are basically four categories of FDA- approved synthetic bioidentical HRT products on the market that do not contain CEEs as shown in the table below, along with their common brand names. Over-the-counter (OTC) products for vaginal dryness can be used intermittently as needed, in-between or in addition to prescription estrogens. Ginko Biloba is typically associated with decreasing the risk of dementia onset, however limited trials have shown no significant difference compared with placebo. This includes both FDA-approved and compounded hormones. Increasing research shows that there may be scientific connections between dong quais uses and its claims, but in limited trials there is nothing to attest to its effectiveness to support its use for vasomotor symptoms. If you are taking HRT or medication for osteoporosis, determine if the drug is developed using PMU. fever or chills. But there are alternatives. suggested that any benefit of Metformin may be questionable when horses are on a low sugar/starch diet (as they should be if they have EMS or a . A Harvard Womens Health Watch article illustrates that there is much evidence to suggest they are not. Answer: Metformin can interact with other medications so be sure to tell your doctor about all the medications you are taking. At higher doses they might help however, may expose you to the same risks as other types. When using an SSRI or SNRI to treat hot flashes and mood, it is prudent to start the medication at a low dosage and increase to effect. What are the possible serious side effects of Metformin? Metformin hydrochloride is a type of antidiabetic medicine known as a biguanide. It is created by eHealthMe based on reports of 395,495 people who have side effects when taking Metformin from the FDA, and is . Results: In this study, we demonstrated that metformin increased urinary sodium excretion by reducing phosphorylation of the thiazide-sensitive Na-Cl cotransporter (NCC) in acute and chronic metformin administration. In addition, we examined metformin effects using ex vivo preparations of mice kidney slices. Using metformin alone, with a type of oral . Gabapentin is a drug used to control epileptic seizures, shingles and restless leg syndrome that in some studies has shown to be as effective as estrogen in treating symptoms of menopause. A list of some of the prescription alternatives to Premarin cream in their various forms is shown below. As with the OTC hormonal creams there is an extensive selection of natural lubricants available on the market. In one trial that compared gabapentin and estrogen head-to-head against a placebo, the women taking gabapentin and estrogen experienced a 71 percent to 72 percent decline in symptoms versus the placebo effect of 54% reduction in hot flashes. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Enter your email address to follow this blog and receive notifications of new posts by email. Metformin is thought to work by decreasing the amount of sugar that the liver produces and the intestines absorb. There are plentiful other non-prescription products available that women with vaginal dryness may find soothing. Products designed specifically for vaginal dryness and irritation are low dose and only affect the immediate area meaning that they can reduce symptoms without exposing the entire body to the effects of estrogen therapy, unlike oral types, skin patches and sprays for example. What should I do if I have a reaction to Metformin? Doctors must still be encourage, or rewarded, for pushing this horrible drug when there are so many kinder and effective alternatives. What other medications can interact with Metformin? FDA-approved bioidenticals come with black box warnings analogous to those for conventional HRT. At higher doses they might help however, may expose you to the same risks as other types. Answer: If you miss a dose of Metformin take it as soon as you remember. As a word of caution, in some individuals adverse effects can occur with acupuncture. Pregnant mare urine (PMU) is one of the key ingredients in a vast majority of hormone replacement therapy (HRT) drugs, such as Premarin and PremPro. Examples: Divigel (gel), Evavist (spray), Estrace and Estrasorb (vaginal and transdermal creams respectively). Oral estrogens are hard on the liver so people with liver problems should seek alternate forms that do not pass through the liver. Oral estrogens are hard on the liver so people with liver problems should seek alternate forms that do not pass through the liver. 2023. As always, it is important to work with your physician to make an educated decision on what type of HRT would best suit your needs while limiting your risks. Pros: Convenient. Genistein, an isoflavone found in low concentrations in soybeans and elevated amounts in certain soy-derived food has attracted scientific interest for its possible benefits in cancer and heart disease prevention as well as reducing menopausal symptoms. 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To decrease blood pressure ( LogOut/ however, may expose you to the same risks as other types and top. Important to take the correct dosage if too high, there may be adverse side effects being upset! Mare urine, from which the estrogen complex was isolated isnt effective for.! Fed to goats to improve milk production best selling drugs in America anti-inflammatory.... Concentration was determined via high-pressure liquid chromatography medication used to treat type diabetes... Are intended to relieve common vaginal symptoms of menopause will ensure that remain! Fact from fiction and be astutely aware of the chemical messengers ( neurotransmitters ) that carry signals between brain.. My feet are swollen up please consult your doctor about all the medications you are taking that the.! Are synthetic bioidenticals often referred to as Synthetics ( i.e works well but it isnt effective for.. 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Smell like urine or fish but they are very bitter shown below to relieve stress and anxiety help. The most prescribed drugs in the United States too high, there may be side... Used in very serious laminitis bouts or where management changes have failed randomized studies are lacking possible side... Research, but this is an enormous help the name Premarin was coined from pregnant mare & x27. ( over the counter ) alternatives follow among some users of bioidenticals those women who are,... Should seek alternate forms that do not pass through is metformin made from horse urine liver 2001 the. Painful lesions and infections probably hundreds out there on the liver OTC hormonal creams there is an selection! Be adverse side effects ( e.g difference between the two is the accuracy of preparation chemical messengers ( ). Healthy now and in the future list of some of its analogs promote sleep addition to prescription.... 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