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Pre=treatment–’agentsshouldbe’given3minutespriortointubation ’(canbe’ giveninanyorder)’ Drug’ Dose’ Indication’ Other’notes’ Background: Propofol is a lipophilic medication shown in pharmacokinetic studies to accumulate over time and potentially cause over sedation in obese patients when dosing is based on total body weight. Propofol Dosage and Administration. The average PropoFlo™ 28 induction dose rates for healthy dogs given propofol alone, or when propofol is preceded by a preanesthetic, are indicated in the table below. 240 mg become the dose ordered, 10 mg is the dose available, 1 mL is the volume available. A brief description of propofol … Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min. The median duration of the propofol maintenance infusion was … For constant infusion, propofol is dosed at 0.05 to 0.3 mg per pound per minute (0.1 to 0.6 mg/kg/min). 100 to 150 mcg/kg/min (primary propofol) 50 to 100 mcg/kg/min (secondary propofol). Propofol (10 mg/mL) (1 - 8 mg/kg) Robenacoxib (20 mg/mL) (2 mg/kg) Tiletamine/ zolazepam (100 mg/mL) (1 - 4 mg/kg) EQUIPMENT AND SUPPLIES: Breathing Circuit. It is the responsibility of the providing veterinarian to decide drug dosages for an … Propofol is slightly soluble in water and, thus, is formulated in a white, oil-in-water 178.27 . Furthermore, many clinicians are co-administering ketamine or fentanyl in conjunction. The dose and rate for propofol … Anesthesia was induced with a median propofol dose of 1.4 mg/kg (range: 0.9 to 6.9 mg/kg) and maintained with a median maintenance propofol dose of 146 mcg/kg/min (range: 68 to 425 mcg/kg/min). Undesirable effects such as cardiorespiratory depression are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in the infusion rate. Propofol is chemically described as 2,6-diisopropylphenol. Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg). (propofol) injectable emulsion, USP is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. Dosing Information of Propofol for Dogs and Cats; Propofol is dosed at 1.5 to 4 mg per pound (3 to 8 mg/kg) intravenous, given slowly over 1 minute. 240/10 x 1 = 24. The structural formula is: C 12 H 18 O M.W. This table is based on field study results and is for guidance only. Propofol blood concentrations at steady-state are generally proportional to infusion rates, especially in individual patients. Maintenance Dosage Guidelines Preanesthetic* Propofol Maintenance Dose Propofol Rate of Administration mg/kg Seconds mg/kg/ min mL/kg/ min None 3.2 60 3.2 0.32 Benzodiazepine/ Opioid 1.7 60 1.7 0.17 Phenothiazine/ Opioid 2.0 60 2.0 0.20 *Doses for preanesthetics may be lower than the label directions for their use as a single medication2. Maximum dose of 15,000 mcg/min. 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