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Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Planta Med 2002;68(2):128-132. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Scutellaria baicalensis root: Uses, There are a number of different names that people use for Baicalin. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Biull.Eksp.Biol Med 1999;128(9):327-329. Lin YK, Yen HR, Wong WR, et al. Ann N Y Acad Sci 2007;1095:521-526. View abstract. Planta Med 2000;66:91-3. 2005 - 2023 WebMD LLC, an Internet Brands company. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. In some cases, this might change the effects and side effects of a medication. Cancer Res 7-15-2003;63(14):4037-4043. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, increasing the risk of hypoglycemia. View abstract. Typical doses (see individual product information): Dried herb: 1 to 2 g 3 times/day; Tea: 240 mL 3 times/day (pour 250 mL of boiling water over 5 to 10 mL of the dried herb and steep for 10 to 15 minutes); Tincture: 2 to 4 mL 3 times/day. View abstract. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. View abstract. We currently have no information for BAIKAL SKULLCAP overview. Facial eczema from a sunscreen: Scutellaria baicalensis, a novel allergen beginning to attract attention. View abstract. View abstract. Burnett BP, Jia Q, Zhao Y, Levy RM. Ye F, Wang H, Jiang S, et al. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Levy RM, Saikovsky R, Shmidt E, et al. Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). Planta Med 1998;64:571-2. View abstract. Liao JF, Wang HH, Chen MC, et al. 2006;63(2):95-96. Limit doses of American skullcap to no more than the package recommendation. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Baikal skullcap might slow blood clotting. 11-28-2000;160(2):219-228. 2004;50(3):279-285. Planta Med 2002;68(2):128-132. It is also used for scarlet fever, headache, irritability, red eyes, flushed face, seizures, epilepsy, hysteria, nervous tension, and to relieve a bitter taste in the mouth. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. 2007;60(5-6):294-297. Your lithium dose might need to be changed. J Med Chem 10-21-2004;47(22):5555-5566. Lee, B. S., Shim, S. M., Heo, J., Pae, H. O., Seo, B. Y., Han, S. Y., Sohn, D. H., Jang, S. I., and Chung, H. T. Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. 11-12-2009;126(2):320-331. Eur J Pharmacol 7-1-2011;661(1-3):124-132. Health Benefits J Nat Prod 1997;60(6):598-601. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect Zhang CZ, Wang SX, Zhang Y, et al. Puri BK, White N, Monro JA. Cancer Sci 2008;99(4):689-695. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Dosage: 39 g/day/adult. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. Bull Exp Biol Med 2004;137(5):471-474. 5. Not enough is known about the safety of Baikal skullcap in children when used long-term. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Chou TC, Chang LP, Li CY, et al. 1989;35(3):331-335. 2007;45(3):403-411. Biol Pharm Bull 2011;34(5):727-733. Li T.T, Xu H.M, and Liang Z.W. View abstract. Therapeutic Research Faculty 2020. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. View abstract. 1-8-2007;245(1-2):269-274. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. View abstract. View abstract. 2010;17(10):760-770. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains Baikal skullcap was safely used in research studies lasting up to 12 weeks. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. View abstract. Indian J Med Res 2008;127(6):610-615. Baikal skullcap might change how quickly the liver breaks down these medications. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Journal of China Pharmacy 2010;21. US Food and Drug Administration (FDA). Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. View abstract. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. Eksp Klin Farmakol 1997;60:49-51. Scutellaria Macrantha , Scutellaria Baicalensis, Family: Lamiaceae. 1997;52(11-12):817-823. 10-18-2009;41(5):578-584. Phytomedicine. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. A., Attele, A. S., Zhang, L., and Yuan, C. S. Anti-HIV activity of medicinal herbs: usage and potential development. In lung tumor models, S. barbata inhibits hypoxia-inducible factor-1 alpha and VEGF expression(18). This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. Kim M, Lee BC. Wang, G. F., Wu, Z. F., Wan, L., Wang, Q. T., and Chen, F. M. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. Studies in humans are quite limited. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. View abstract. Planta Med 2001;67(4):331-334. You may ask and answer a query. View abstract. Ceska.Slov.Farm. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Taking Baikal skullcap along with medications that also slow clotting might increase the chances of bruising and bleeding. Z Naturforsch.C. Pharmacol.Res. Int J Oncol. Clin Pharmacol Ther 2007;83:471-6. Yao Xue.Xue.Bao. Planta Med 2003;69(4):300-304. Some medications are moved in and out of cells by pumps. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. View abstract. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. And other Products is for general health information only binding and metabolism of benzo [ ]... Bull Exp Biol Med 2004 ; 137 ( 5 ):727-733 lung cancer is with. When used long-term different names that people use for Baicalin chou TC, Chang LP, Li CY, al. 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