WHO guided real time stability testing on Shankhpushpi Syrup. 3). Moreover, it has also been proposed that the anti-convulsant activity of a phyto-medicine is escalated by the presence of certain functional groups like, quinoline, quinazoline, thiazole, benzothiazines, oxadiazole, pyridine, pyrazole, imidazole, pyrimidine, phthalazine, triazine, triazoles, cyclopropane carboxylate, and oxime ether (Wei etal., 2015; Song and Deng, 2018). Wang S. B., Jang J. Y., Chae Y. H., Min J. H., Baek J. Y., Kim M., et al. Nasri H., Shirzad H., Baradaran A., Rafieian-Kopaei M. (2015). The animals did not show any toxicity or behavioural changes up to the dose of 5,000 mg/Kg (Agarwal etal., 2014). will also be available for a limited time. The histopathology of brain also did not show any aberrations or degeneration of neurons. The fundamental bioactive compounds responsible for the nootropic activities of this herb have been identified as 4'-methoxy kaempferol, 7-methoxy quercetin, convolamine, scopoletin, ceryl alcohol, -sitosterol and hydroxy-cinnamic acid. 2009, Ali Al-Rawi, Flowering plants of Kuwait, 1985, Flora of Eastern Saudi Arabia by Rain and Dust at Flickr. Furthermore, in Unani medicinal system, a syrup prepared with C. prostratus and Piper nigrum is prescribed in bleeding piles and venereal diseases (Khare, 2004). In such a scenario, safer herbal alternative medicines play a vital role in managing the neurological etiologies. Tseomashko N. E., Terent'Eva E. O., Kodirova D. B., Okhunov I. I., Aripova S. F., Khashimova Z. S., et al. Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis, Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals. It also activates the sleep inducing areas of the brain, namely, preoptic nucleus (L). A. Hoang M. H., Jia Y., Mok B., Jun H. J., Hwang K. Y., Lee S. J. [2] The Ayurveda preparation shankapushpi is, according to most sources, identical with Convolvulus prostratus, but some say shankapushpi is instead Clitoria ternatea.
Islam S. M. S., Purnat T. D., Phuong N. T. A., Mwingira U., Schacht K., Frschl G. (2014).
Methanolic extract of this plant (5001000 mg/Kg) also exhibited anti-convulsant activity, as characterized by reduction in the mean recovery time of convulsions in case of maximal electroshock seizure model in mice (Kaushik, 2017). The ensuing sections will provide an ethnomedicinal, phytochemical and pharmacological update of this cognitive booster herb, C. prostratus (CP). Similar views had been presented in Chikitsasangraha written by Chakradatta; Kaideva Nighantu; and Ayurveda Saar Sangraha (Khare, 2004). Neurological disorders constitute a significant proportion as the leading causes of death among all the other non-communicable diseases (Gourie-Devi, 2014). Five hundred mg/Kg concentration of the CP extracts have shown statistically significant (p < 0.001) protection against strychnine and PTZ induced clonic convulsions (Ratha and Mishra, 2012; Siddiqui etal., 2014). C. prostratus (CP) contains volatile oil; fatty alcohols; flavonoids, i.e. Phyto-constituents belonging to diverse chemical families, namely, coumarins, alkaloids and polyphenols (see This herb exhibits anti-convulsant, anti-depressant, anxiolytic, sedative, anti-inflammatory, anti-oxidant, analgesic, nootropic, spasmolytic and neuroprotective activities. Isolation and characterization of glycosides from Convolvulus prostratus, Ficus virens, Phoenix dactifera, Spondias mangifera and Terminalia belerica. These phytoconstituents most probably act as GABA-A-benzodiazepine agonists and bind to the GABA-A-benzodiazepine receptors, thereby causing an increase in the chloride ion flux and consequent hyperpolarization of the postsynaptic membrane. CP also acts as GABA-A agonists and binds to lateral prefrontal cortex (O) and anterior cingulate cortex (N). Sign in|Report Abuse|Print Page|Powered By Google Sites. Plants with anticonvulsant properties: a review. The new PMC design is here! Cheriyan B. V., Sr., Kadhirvelu P., Sr., Nadipelly J., Jr., Shanmugasundaram J., Sayeli V., Sr., Subramanian V., Sr. (2017). Table 2 One such example is Convolvulus prostratus Forssk. Hence, natural compounds serve as the holistic option which act on multiple neural targets and are enriched with free radical scavenging polyphenolic compounds (Park etal., 2018). Prostrate herb from Bihar for id:Collected from Bhojpur district plains. for a possibility to participate in their field excursions and to learn about local nature. This CP herb has also been reported for several other pharmacological activities, including anti-diabetic, anti-hyperlipidemic, anti-hypertensive, anti-microbial, anti-platelet aggregation, anti-ulcer, cardio-vascular, hepatoprotective, and hypothyroidism (Barar and Sharma, 1965; Mudgal, 1975; Rizk etal., 1985; Mali, 1995; Jain etal., 2011; Ravichandra etal., 2013; Jalwal etal., 2016). Shankpushpi- which species? and transmitted securely. Bihaqi S. W., Sharma M., Singh A. P., Tiwari M. (2009).
Ravichandra V. D., Ramesh C., Sridhar K. A. Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats, https://www.ijser.org/paper/Estimation-of-elemental-concentrations-of-Indian-medicinal-plants-using-Energy-dispersive-X-ray-fluorescence.html, https://www.ijpp.com/IJPP%20archives/1965_9_2/99-102.pdf, https://www.semanticscholar.org/paper/Ethnobotany%2C-Phytochemistry-and-Pharmacology-of-Bhalerao-Verma/62602df9affb6d3a5a27699015e1506aa34ef1bf, http://www.phytojournal.com/vol1Issue1/Issue_may_2012/4.pdf, https://www.semanticscholar.org/paper/SCREENING-FOR-ANTIDEPRESSANT-LIKE-ACTIVITY-OF-IN-Dhingra-Valecha/51168240f3c88647a52ce21a54878606c61a7c66, https://irjponline.com/admin/php/uploads/794_pdf.pdf, https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/1109757, http://www.thepharmajournal.com/archives/?year=2016&vol=5&issue=1&ArticleId=695, https://pdfs.semanticscholar.org/1dc0/39b0046a0caa7e211b7a64f0ec91596d4fef.pdf, https://www.pharmatutor.org/articles/development-high-performance-thin-layer-chromatography-method-for-determination-scopolin-convolvulus-pluricaulis-chois?page=1%2C1, https://www.researchgate.net/publication/266140204_Hypolipidemic_effect_of_Convolvulus_microphyllus_in_cholesterol_fed_gerbils_Meriones_hurrinae_Jerdon, https://www.semanticscholar.org/paper/Review-on-ethnomedicinal-uses-and-of-memory-herb-Sethiya-Mishra/427692942318bd7bf5c9cd65e2cf8627aaa9c61f, http://globalresearchonline.net/journalcontents/v23-2/36.pdf, https://www.semanticscholar.org/paper/REVIEW-OF-SANKHAHAULI-(CONVOLVULUS-PLURICAULIS-FROM-Nisar-Khan/0994b296aed35c7b9ccaa97be1505fddf55218e8, https://www.ijam.co.in/index.php/ijam/article/view/163, https://ijpbs.net/abstract.php?article=NTk2, http://nopr.niscair.res.in/handle/123456789/27919, http://www.phytojournal.com/archives/2013/vol2issue4/PartB/23.1.pdf, https://pdfs.semanticscholar.org/696f/2e4d7280727d2baba08bc7c6e3a7cd03ef3a.pdf, Decoction of this herb used along with milk (, Intact parts used for treating anxiety neurosis (, Whole plant used for the management of arthritis, osteoarthritis and rheumatic pain (, Paste of flowers and leaves used for the management of fracture (, Intact parts used for the management of constipation (, Paste of roots and flowers administered for the treatment of dementia (, Paste of leaves (100 g) along with black pepper (3-4 grains) is to be administered once daily (, Jelly obtained from this plant (10 g) is mixed with honey (10 g) and is to be taken thrice a day (, Paste of this plant along with cumin seeds (l g) and milk thrice a day (, Juice of the leaves has to be administered at a dose of 10 mL, thrice a day (, Powder of plant (3 g) mixed with sugar (5 g) and milk (20 ml) is to be taken twice daily (, Paste of this plant is taken along with milk (, Decoction of this herb is used along with cumin and milk for treating attention deficit hyperactivity disorder (ADHD), mild convulsions, depression, emotional stress, mental debility, memory loss, mental hypersensitivity, schizophrenia and stress disorders (, Intact parts used for the management of excessive thirst (, Intact parts used for alleviating fever (, Intact parts used for the management of heart burn or pyrosis (, Decoction of this herb is used along with cumin and milk (, This plant (100 g) is ground with little water and taken with sugar or honey once daily, for 21 days (, One tea spoon powder of dried plant is taken for the management of stomachache (, A syrup prepared from this herb is used for the management of vertigo (, Improves scopolamine-induced spatial memory impairment (, Antihypoxic, immune-modulating, and anti-inflammatory activity (, Antioxidant, anti-mutagenic, anti-inflammatory and antiangiogenic (, Antioxidant, photooxidant activity; strong inhibitory effect on the tumour U14 (, Activates LXR- and suppresses SREBP-1 to enhance symptoms in metabolic syndromes; potent inhibitory effect on, Antioxidant activity; stimulator of recombinant SIRT1 and also a PI3K inhibitor; attenuated the function VEGFR, androgen receptor and the expressions of NF-B, IL Receptor, FAK, ERK, Nrf2 (, Antifungal, anti-allergic, anti-aging and hypouricemic activities (, Antinociceptive activity; acetylcholinesterase (AChE) inhibitor; fungitoxic activity (, Anti-inflammatory; anti-cancerous activity (, Anti-inflammatory; anti-proliferation; anti-pyretic; pro-apoptotic activity (. One such cognitive booster herb is C. prostratus Forssk., commonly known as Shankhpushpi, which is mainly endowed with neuroprotective, nootropic and neuro-modulatory activities ( Quintans Jnior L. J., Almeida J. R., Lima J. T., Nunes X. P., Siqueira J. S., Oliveira L. E. G. D., et al. Leaf, habitat, location, elevation, dateare also vital in identifying. The polyphenols present in this species act as reactive oxygen species (ROS) quenchers, thereby ameliorating the oxidative stress that is generated as a diabetic manifestation. 1 post by 1 author. Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-, NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. Singh V. K., Govil J. N., Hashmi S., Singh G. (2003). In recent years, non-communicable diseases (NCDs) have become an emerging cause of morbidity and mortality (~ 12% global prevalence) (Islam etal., 2014). Johnson C. D., Barlow-Anacker A. J., Pierre J. F., Touw K., Erickson C. S., Furness J. Similarly, the iron oxide nanoparticles of the CP herb exhibited maximum tolerable dose up to 2,000 mg/Kg in Swiss albino mice with no clinical signs of toxicity. The ethanolic extract of CP at dose 750 mg/Kg showed statistically significant analgesic activity as compared to the standard analgesics like, morphine sulphate, when tested in hot plate method and tail-flick assays in rats (Agarwal etal., 2014). Bhowmik D., Kumar K., Paswan S., Srivatava S., Yadav A., Dutta A. This phytoconstituent acts as a cardiac depressant, ultimately leading to a fall in blood pressure, which gets gradually normalised (Dwoskin and Crooks, 2002; Sethiya etal., 2009). Siddiqui N. A., Ahmad N., Musthaq N., Chattopadhyaya I., Kumria R., Gupta S. (2014). All the above mentioned ethnomedicinal uses of C. prostratus have been tabulated in about navigating our updated article layout. Jain A., Kaur J., Bansal Y., Saini B., Bansal G. (2017). The CP ethanolic extract has exhibited spasmolytic activity in isolated rabbit ileum, isolated rat uterus, intact intestine and tracheal muscles of dog (Barar and Sharma, 1965). 7), Regulation of neural ion channels by muscarinic receptors, The human brain book: An illustrated guide to its structure, function, and disorders. In another study, CP methanolic extract was evaluated for anxiolytic activity on Obsessive Compulsive Disorders (OCDs) in mice by employing marble burying behaviour analysis, hole board and rota-rod tests. Mental, neurological and substance abuse disorders: Strategies towards a systems approach. Aegypt. Similarly, in the cosmeceutical industry, the CP herb is used as a general tonic for rejuvenating the skin and hairs, thereby treating skin related ailments as well as keratogenic disorders. Besides Ayurveda, C. prostratus (CP) has also been used in Siddha system of medicine, wherein an oil obtained from this plant is used as a keratogenic agent for promoting hair growth (Gogte, 2012). Such extensive industrial uses of CP further confirms the holistic significance of this nontoxic wonder herb (Jalwal etal., 2016). EPM test has mainly been used to investigate the interactions between aversive memory and anxiety responses of the mice. The fundamental mechanism behind such evident anti-convulsing activity of CP might be the presence of coumarins and triterpenoids (Quintans Jnior etal., 2008).
Srinivas T. L., Lakshmi S. M., Shama S. N., Reddy G. K., Prasanna K. R. (2013). It is hoped that the scientific update on the ethnomedicinal aspects of this herb would thrive research propagation and development of the CNS phytopharmaceuticals, originated from C. prostratus. In a study, Rawat and Kothiyal have also found that the aquo-methanolic, ethanolic and petroleum ether extracts isolated from CP (50400 mg/Kg) exhibited anxiolytic, memory-enhancing and nootropic activity as evaluated by using Elevated Plus Maze (EPM) and step-down models in mice. Report submitted to the National Commission of Macroeconomics and Health. PT analyzed the information, generated the artwork, and co-wrote the manuscript. Indeed, many such functional groups have been found in the CP phyto-constituents ( Hence, the presence of phytoconstituents such as convolvine might be responsible for endowing CP with the abilities to regulate all the neuronal factors/proteins and enzymes, thereby showcasing its evident neuroprotective status (Sethiya etal., 2009; Ray and Ray, 2015). ) for e.g., quinones, microphyllic acid, 6-methoxy coumarin, 4'-methoxy kaempferol, 7-methoxy quercetin, vanillic acid, syringic acid and melilotic acid (Daniel, 2016). Gapparov A. M., Okhunov I. I., Aripova S. F., Nabiev A., Khuzhaev V. U. This medicinal herb has been reported to contain many bioactive phytoconstituents, such as, alkaloid (convolamine), flavonoid (kaempferol) and phenolics (scopoletin, -sitosterol and ceryl alcohol), that have been ascribed to the observed medicinal properties. No use, distribution or reproduction is permitted which does not comply with these terms. Malik S., Ahmad S., Sadiq A., Alam K., Wariss H. M., Ahmad I., et al. Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. CP deactivates the wake promoting areas, namely, tuberomamillary nucleus (J) located in the hypothalamus (K), locus coeruleus (I) and raphe nucleus (H). Park C., Moon D. O., Rhu C. H., Choi B. T., Lee W. H., Kim G. Y., et al. For better viewing of species' pages, colour scheme & formatting is being followed as: Description of the species, Details of other flora species on the same page, Uses/ harms, Distribution, Abundance/ Location/ Flowering time & date, Habit & habitat, Etymology & pronunciation, Other interesting information, stories etc., Others, Botanical names, Common names, Main point of discussion below, Discussion about Botanical names. There are various herbs which are used in traditional medicine for the management of neurodegenerative diseases, for instance: Centella asiatica (L.) Urb., Glycyrrhiza glabra L., Tinospora cordifolia (Willd.) The use of herbal medicines continues to escalate rapidly with about 70% of the world population still relying upon traditional medicines for their primary healthcare needs. Besides, it also possesses several other therapeutic properties, such as immunomodulatory, antimicrobial, antidiabetic and cardioprotective activities. Before The chloroform, ethanol and aqueous extracts of CP have been evaluated for anti-convulsant activity against strychnine induced as well as pentylene tetrazol (PTZ) induced convulsive seizures in different animal models. (1985). Received 2019 Sep 16; Accepted 2020 Feb 7. (Billore etal., 2005; Amin etal., 2014). For any mistake in identification or for becomingefloraofindia e-groupmember (for contributingtowards building of efloraofindia or otherwise), pl. In such a case, the therapies initiated after the onset of neuropathological asymptomatic etiologies will only have limited value for the patients (Solanki etal., 2016). (2008). Modulation of PPAR expression and activity in response to polyphenolic compounds in high fat diets. Such reduction in the tau protein expression is responsible for causing an amelioration in the amyloid -induced deficits in case of neurodegenerative disorders such as Alzheimer's disease (Vossel etal., 2010). Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment. 203. CP plant also contains other alkaloids (convolamine, convosine, convoline, convolidine, convolvine, confoline, evolvine, phyllabine, subhirsine, sankhpuspine) (Agarwa etal., 2014; Balaji etal., 2014); anthroquinones; carbohydrates (D-glucose, sucrose, rhamnose, maltose) (Dhingra and Valecha, 2007; Bhowmik etal., 2012; Agarwa etal., 2014); coumarins (ayapanin, scopolin, scopoletin); flavonoids (kaempferol, quercetin) (Lal, 2014); glycosides (geranilan-3-ol-1-carboxylate-1-O--D-xylopyranosyl-(21)-O--D-xylopyranoside (Sultana etal., 2018); phenolic compounds; steroids; tannins; and terpenoids (Ravichandra etal., 2013; Agarwa etal., 2014; Balaji etal., 2014; Malik etal., 2016). f. & Thomson, Bacopa monnieri (L.) Wettst. QNHG (Qatar Natural History Group) and associated people, Convolvine also aids in potentiating the effect of another muscarinic memory enhancer, namely, arecoline, thereby imparting nootropic abilities to CP (Sethiya etal., 2009). PMC legacy view ) are responsible for such evident neuro-pharmacological profile of the CP plant (Nolte, 1999; Carter, 2014). and gokhru (Tribulus terrestris L.) in the management of hypertension. (2013). Anyways, looks matching with the limited image! The Na+/K+ ATPase pump aids in maintaining the osmotic equilibrium and membrane potential in neuronal cells (Forrest, 2014). (2015). The anti-ulcerogenic effect was largely observed due to upregulation of mucosal defensive factors such as mucin and glycoprotein secretion, which in turn was induced by the flavonoids and steroids present in this herb (Srinivas etal., 2013). Sultana S., Ali M., Mir S. R., Iqbal D. (2018). All authors agreed with the final version of this manuscript. Department of Allied and Applied Sciences, University of Patanjali, Haridwar, India. aegypt.-arab. (2015). Domnguez-Avila J., Gonzlez-Aguilar G., Alvarez-Parrilla E., de la Rosa L. (2016). ) (Malik etal., 2011; Amin etal., 2014; Siddiqui etal., 2014). The Rachitha P., Krupashree K., Jayashree G. V., Kandikattu H. K., Amruta N., Gopalan N., et al. AV investigated and supervised the findings of the work. Xing N., Chen Y., Mitchell S. H., Young C. Y. Database on medicinal plants used in Ayurveda (Vol. official website and that any information you provide is encrypted Several other hydrocarbons, namely, 1- pentyl-2-tridecanyl cyclopentyl cyclohexane carboxylate, 1,2-benzenedicarboxylic acid, 10-bromodecanoic acid, 1-octadecanesulphonyl chloride, 2-butanone, 2-pentanol, 7- hydroxyheptadecanyl-1,7, 17-tricarboxylic acid, ascorbic acid, cyclononasiloxane, cyclo-octadecanyl methanol, decanoic acid, dicyclohexyl cyclo-octyl acetic acid, eicosane, heneicosane, hydroxy cinnamic acid, octatriacontyl pentafluoropropionate, pentadecyl 2-propyl ester, pentanoic acid, pentyl hexacosanoate, phthalic acid, silane, squalene, tetracyclohexanyl caproate and tridecane are also found in the extract of the CP plant (Bhalerao etal., 2014; Malik etal., 2016; Rachitha etal., 2018; Sultana etal., 2018). Figure 1B ) (Siddiqui etal., 2014). Shankhpushpi has been used traditionally as a brain tonic and is believed to help a wide range of issues. A., Maaz M., Shiffa M. (2012). Most of the neurodegenerative disorders are progressive in nature, and the cycle of etiological events usually have an early-onset which might get unnoticed or under-detected. Besides, this plant has manifold therapeutic utilities, wherein, a decoction of its shoots is used as a remedy for anaemia and weakness (Singh etal., 2003). Gururaj G., Girish N., Isaac M. K. (2005). Aleebrahim-Dehkordy E., Tamadon M. R., Nasri H., Baradaran A., Nasri P., Beigrezaei S. (2017). Rathee P., Chaudhary H., Rathee S., Rathee D., Kumar V., Kohli K. (2009). In-Vitro Evaluation of Antioxidant Activity and Total Phenolic Content of Methanolic Extract of Convolvulus pluricaulis, Preliminary pharmacological studies on Convolvulus pluricaulis choisan Indian indigenous herb, Chemical investigation of Convolvulus pluricaulis Chois, Old and new natural products as the source of modern antithrombotic drugs. Additionally, the fundamental principle responsible for the cardio-vascular activity of this herb has been proposed to be linked with it alkaloid derivative, evolvine hydrochloride, which is known to exhibit lobeline-like action on the cardiovascular system. Neurodegenerative diseases: from available treatments to prospective herbal therapy, Recent developments on triazole nucleus in anticonvulsant compounds: a review. The CP herb has also been used as a phyto-ingredient of a polyherbal medicinal formulation: Sankhahauli, which contains leaves of C. prostratus (15 g); seeds of Piper nigrum (3 g) and Papaver somniferum (20 g); whole plant of Prunus amygdalus (10 g), Vitis vinifera (20 g) and Coriandrum sativum (10 g). Tognolini M., Barocelli E., Ballabeni V., Bruni R., Bianchi A., Chiavarini M., et al. (2011). Neuropharmacological profile of extracts of aerial parts of Convolvulus pluricaulis Choisy in mice model. In addition, CP is known to be a good source of vitamins and minerals, namely, calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sulphur, zinc, vitamin C and E (Sethiya etal., 2010; Babu etal., 2015). Synthesis of convolinine and cytotoxic activity of alkaloids of the genus Convolvulus and their derivatives, Vinholes J., Silva B. M., Silva L. R. (2015). Shaded rows indicate specific neurological diseases which can be managed by the administration of C. prostratus. A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines, Attenuating effect of bioactive coumarins from Convolvulus pluricaulis on scopolamine-induced amnesia in mice, ). Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum - A way to overcome sunflower head rot. Tonda-Turo C., Origlia N., Mattu C., Accorroni A., Chiono V. (2018). Sethiya N. K., Trivedi A., Patel M. B., Mishra S. H. (2010). Similar results have also been observed in case of the ethanolic extract of the CP flower petals at doses 200400 mg/Kg in mice (Kaushik, 2017). Additionally, the presence of vitamin E in this herb also aids in controlling the levels of protein oxidation and lipid peroxidation, thereby leading to an escalation in the antioxidant defense system (Cowan, 1999; Nasri etal., 2015; Domnguez-Avila etal., 2016; Foretz etal., 2018). Ekhlas M. M. Abdel Bary, The Flora of Qatar, Volume I: The Dicotyledons. Jalwal P., Singh B., Dahiya J., Khokhara S. (2016). Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. The ethanolic and aqueous extracts of the CP leaves have been evaluated for acute oral toxicity study in albino Wistar rats. Moreover, an alkaloid, namely, convolvine present in this herb has also been found to block cholinergic muscarinic receptors: M2 and M4. Furthermore, the aqueous extract of CP roots diminished the endogenous levels of reactive oxygen species in tauopathy flies as induced by overexpression of -protein, thereby substantiating its oxidative stress ameliorative effect (Olakkaran and Antony, 2017). 203. Similar results have been observed in case of aluminium chloride induced neurotoxicity in rat cerebral cortex. It ultimately acts as a sedative moiety which initiates a persistent fall in blood pressure and cardiac contraction, thereby managing neurological pathologies, such as anxiety, insanity and epilepsy (Chaudhary, 1996). Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: reverse pharmacology and bedside to bench approach. Adams M., Gmnder F., Hamburger M. (2007). However, these strategies have also shown little success. Billore K. V., Yelne M. B., Dennis T. J., Chaudhari B. G. (2005). Convolvulus prostratus..Indira Park,Ambala cantt,dated 26th april 2013 :Attachments (2). You can help Wikipedia by expanding it. sharing sensitive information, make sure youre on a federal Authors gratefully acknowledge the efforts of Dr. Shivam Singh and Dr. Swami Narsingh Dev at Patanjali Research Institute, for their help in data collection and processing. Polyphenols, flavonoids and vitamin E present in the CP plant act as reactive oxygen species (ROS) scavengers and also ameliorate the lipid peroxidation, thereby attributing towards the anti-oxidant activity of CP (Nasri etal., 2015). This Medicinal plants-related article is a stub.
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