point-of-care microfluidics

2022.07.31
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point-of-care microfluidics

It is organized by diagnostic test category highlighting some key developments in the area. Therefore, blood contains significant information about systemic function. ; writingreview and editing, S.-M.Y. The system effectively integrates the paperfuge and an immunoassay unit that can analyze biomarkers in blood while centrifuging. ; Gregory, M.E. These diseases have a long duration, progress slowly, and do not spread from person to person. A paper-based colorimetric molecular test for SARS-CoV-2 in saliva. Although exosomes have potential as tools for cancer detection and monitoring, they are small and of low density; therefore, they are time-consuming and expensive methods, such as those featuring ultracentrifugation, immunomagnetic beads, or commercial kits that are required for analysis. PDMS and thermoplastic molding methods are typically used in microfluidic manufacturing [, We needed only to make the template of a PDMS microfluidic chip in a dust-free room to carry out continuous replication and production, which really makes it easier for us to design and manufacture the chip in the early stage of the experimental project; however, PDMS-based microfluidic chips still have some shortcomings. ; Drummond, C.K. Microfluidic equipment based on PDMS, paper, and 3D printing and systems integrating microfluidics and smartphones is described in the following sections. Cockerham, W.C.; Hamby, B.W. Finally, the information is sent to a remote server, enabling doctors to view the patients electronic health records and leave comments or suggestions for the patient [, The rapid and simultaneous detection of DNA and protein biomarkers is also critical for the detection and monitoring of CVDs. Diagnostic technologies for COVID-19: A review. Label-free biodetection using a smartphone. Patterned paper as a platform for inexpensive, low-volume, portable bioassays. nanopore nanotechnology healthcare Mass spectrometry can identify and accurately quantify thousands of proteins from complex samples [, Numerous conventional medical detection technologies have incorporated microfluidic POC devices. You seem to have javascript disabled. ; Himmelfarb, C.D. ; Akbari, M. Microfluidic-mass spectrometry interfaces for translational proteomics. Gong, M.M. ; Mandal, D.; Zhuang, S.; Lee, E.S. ; Mykhalovskiy, E.; Worthington, C.; Gmez-Ramrez, O.; Gilbert, M.; Grace, D. Pay to skip the line: The political economy of digital testing services for HIV and other sexually transmitted infections. Salivary diagnostics on paper microfluidic devices and their use as wearable sensors for glucose monitoring. ; Hoeve, W.V. Reynolds, R.; Dennis, S.; Hasan, I.; Slewa, J.; Chen, W.; Tian, D.; Bobba, S.; Zwar, N. A systematic review of chronic disease management interventions in primary care. Data will be made available based on request. Park, S.; Zhang, Y.; Lin, S.; Wang, T.H. Ratre, Y.K. The statements, opinions and data contained in the journals are solely The device is composed of three modules. ; Tobos, C.I. The role of serology testing to strengthen vaccination initiatives and policies for COVID-19 in Europe. The system was proven to be effective for cancer diagnosis and liquid biopsies. Yang, K.; Peretz-Soroka, H.; Liu, Y.; Lin, F. Novel developments in mobile sensing based on the integration of microfluidic devices and smartphones. The system successfully performed ELISA analysis of carcinoembryonic antigen and alpha fetoprotein from human blood samples. ; Sannam Khan, R. Role of salivary biomarkers in detection of cardiovascular diseases (CVD). Rama, E.C. Microfluidics will play a vital role in the revolution in point of care diagnostics that is set to take place over the next decade. The system could have a substantial influence on the epidemiology of the disease. Yetisen, A.K. ; Kvedar, J.C.; Woolliscroft, J.O. Patients with chronic diseases tend to require long-term supervision, observation, or care [, Anemia is a common chronic disease and iron deficiency anemia is the most common type. Sahin, O.; Elitas, M.; Yapici, M.K. ANTS, Help us to further improve by taking part in this short 5 minute survey, A Dynamic Imaging Simulation Method of Infrared Aero-Optical Effect Based on Continuously Varying Gaussian Superposition Model, Vegetable Size Measurement Based on Stereo Camera and Keypoints Detection, https://creativecommons.org/licenses/by/4.0/. ; Li, K.H. Telecommun. lab disc chip rsc microarray lysis thermoplastic elastomer tpe detection cellular integrated point care microfluidic pdms microelectrodes functionalized biosensors inkjet

Brawer, M.K. ; Mandizvo, T.; Rogich, J.; Kunota, T.T.R. ; Yetisen, A.K. Adv. Carcinoembryonic antigens (CEA) and alpha fetoproteins (AFP), Fully Integrated hand-powered centrifuge and analysis paper-based microfluidic device (. ; Mackay, D.; Lewsey, J.; Gray, S.R. Aebersold, R.; Mann, M. Mass spectrometry-based proteomics. Taparia, N.; Platten, K.C. ; Hesselink, L.; Davis, R.W. There are many on-site detection and diagnosis POC devices in the market, including but not limited to glucose detection and infectious disease monitoring; however, among the POC detection devices, microfluidic POC devices with POC integrated microfluidic technology occupy the vast majority of the share, because microfluidic POC devices can allow fluid operation and detection to be carried out in the same device, which is more integrated than non-microfluidic POC devices. This information could be used by doctors to judge the condition of the patients heart and nervous system for the early detection of CVD and determination of the neurological system disease risk [, Telemedicine is another potential direction for research on future POC technologies. ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. Microfluidic platforms for point of care (POC) medical diagnostics. Li, J.; Sun, Y.; Chen, C.; Sheng, T.; Liu, P.; Zhang, G. A smartphone-assisted microfluidic chemistry analyzer using image-based colorimetric assays for multi-index monitoring of diabetes and hyperlipidemia. ; Joung, H.A. Telemedicine and the COVID-19 pandemic, lessons for the future. Sun, C.; Liu, L.; Prez, L.; Li, X.; Liu, Y.; Xu, P.; Boritz, E.A. Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy. Mobile sensors based on integrated microfluidic devices and smartphones, Microfluidic chip, smart phone, external sensors, Integration of a mobile phone and microfluidic chip. ; Mongersun, A.; Chau, H.; Araci, I.E. Bhamla, M.S. ; Lakshmipriya, T.; Chen, Y.; Phang, W.M. These detection methods must become more widespread, and a method to achieve this goal is microfluidic technologies. Advancing point-of-care (PoC) testing using human saliva as liquid biopsy. Mandal, N.; Pakira, V.; Samanta, N.; Das, N.; Chakraborty, S.; Pramanick, B.; RoyChaudhuri, C. PSA detection using label free graphene FET with coplanar electrodes based microfluidic point of care diagnostic device. Li et al., improved the system and designed a paper-based integrated diagnosis system. First, utilizing PDMS to produce chips is not suitable due to a great demand for the output of chips in large-scale production. Lim, J.; Kang, B.; Son, H.Y. Rissin, D.M. ; Li, Y.; Xin, H.N. Thermoplastic polymers (used for FDM) or photocurable resins (used for SLA). The DNA methylation of tumor suppressor genes has been recognized as a diagnostic biomarker for early tumorigenesis.

Beavis, K.G.

those of the individual authors and contributors and not of the publisher and the editor(s). A systematic analysis of global anemia burden from 1990 to 2010. Papadakis, G.; Pantazis, A.K. Su, W.; Li, H.; Chen, W.; Qin, J. Microfluidic strategies for label-free exosomes isolation and analysis. Zhang, X.; Wu, D.; Miao, F.; Liu, H.; Li, Y. Personalized hemodynamic modeling of the human cardiovascular system: A reduced-order computing model. After standardization, the industries can become more efficient, and the time and cost of the development process can be reduced. Conceptualization, S.-M.Y., S.L. ; Garca-Snchez, P.; Convine, N.; Rosser-James, A.; Tyler, M.; Bandoo, K.; et al. ; Paixo, T.R.L.C. ; Urban, G.A. ; Yang, S. Advances in microfluidic PCR for point-of-care infectious disease diagnostics. Chang, K.W. ; Rudakov, G.; Pillai, D.; Koziol, J.; Schoonmaker, J.P.; Johnson, T.; Verma, M.S. 3D microfluidic paper analysis device (PAD). Increasingly networked global transportation and rapid changes in the natural environment have increased the impact of illness on public health. Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Chakraborty, I.; Maity, P. COVID-19 outbreak: Migration, effects on society, global environment and prevention. Li, D. 5G and intelligence medicineHow the next generation of wireless technology will reconstruct healthcare? Dinter, F.; Burdukiewicz, M.; Schierack, P.; Lehmann, W.; Nestler, J.; Dame, G.; Rdiger, S. Simultaneous detection and quantification of DNA and protein biomarkers in spectrum of cardiovascular diseases in a microfluidic microbead chip. Ray, A.; Esparza, S.; Wu, D.; Hanudel, M.R. The assay had high sensitivity and specificity. Addario, G.; Djudjaj, S.; Far, S.; Boor, P.; Moroni, L.; Mota, C. Microfluidic bioprinting towards a renal in vitro model. Carrilho, E.; Martinez, A.W. ; Wu, T.C. ; Angell, J.B. A Gas chromatographic air analyzer fabricated on a silicon wafer. Conventional medical testing methods require specialized laboratory equipment and well-trained operators, limiting the applicability of these tests. Xu, D.; Huang, X.; Guo, J.; Ma, X. ; Mahilum-Tapay, L.; Lee, H. Sample preparation: A challenge in the development of point-of-care nucleic acid-based assays for resource-limited settings. Shi, Y.; Cai, Y.; Cao, Y.; Hong, Z.; Chai, Y. Rajendran, M.; Nachbagauer, R.; Ermler, M.E. We also describe some of the important developments such as smartphone integrated tests and the challenges in taking microfluidic technologies to market. Although DEP technology and microfluidic technology have many applications, there are still many challenges to realize a POC application. We use cookies to help provide and enhance our service and tailor content and ads. ; Song, L.; Rivnak, A.J. articles published under an open access Creative Common CC BY license, any part of the article may be reused without and Y.C. ; Obaje, E.A. ; Hackett, B.A. In Proceedings of the 2020 21st International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Microelectronics and Microsystems (EuroSimE), Cracow, Poland, 58 July 2020. ; Larson, D.F. ; de Oliveira, O.N. Wearable sensors for COVID-19: A call to action to harness our digital infrastructure for remote patient monitoring and virtual assessments. DEP is a major electrical phenomenon in electrical technology. Nilsson, T.; Mann, M.; Aebersold, R.; Yates, J.R.; Bairoch, A.; Bergeron, J.J.M. ; Fulton, A.L. ; Kang, T.; Moon, J.; Lee, J.J.; Seo, S.B. ; Tran, P.L. ; Bhaskar, L.V.K.S. Readers of this review will obtain a more comprehensive understanding of the current state of microfluidic technologies for early disease detection. ; Chou, C.Y. ; Phillips, S.T. ; Suchdev, P.S. Sharma, A.; Badea, M.; Tiwari, S.; Marty, J.L. ; Gopinathan, P.; Chung, Y.D. Data and image processing capabilities of integrated system are key for POC detection. Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review ; Lange, P.H. ; Bansal, H.; Sharma, D. Comparison of salivary and serum glucose levels in diabetic patients. Therefore, in the actual application, the manufacturing of microfluidic chips with thermoplastic elastomers is more widely used [, Paper-based microfluidic systems have become popular in practice due to their low cost, ease of manufacture, and portability. ; Dextre, A.; Pascual-Garrigos, A.; Mohan, S.; Putikam, S.V.S. For example, it can centrifuge whole blood but it cannot effectively collect relevant samples. Kadimisetty, K.; Song, J.; Doto, A.M.; Hwang, Y.; Peng, J.; Mauk, M.G. ; Ramos-Payan, M.; Mellors, J.S. AI for infectious disease modelling and therapeutics. Secondly, the differences of the cell molecules and physiological states will also lead to changes of the dielectric properties, which leaves many applications in the experimental stage only and which cannot be put into use. The device has high sensitivity and specificity in isolating and detecting cancer-specific exosomes from patients urine. Approximately 37 million people are estimated to have HIV globally [, Tuberculosis is a fatal infectious disease that can spread rapidly through respiration. Park, J.; Han, D.H.; Park, J.K. microfluidics makuta molding microfluidic injection Microfluidic device for one-step detection of breast cancer-derived exosomal mRNA in blood using signal-amplifiable 3D nanostructure.

Additionally, those in the microfluidic field should increase their investment in biomedical applications and attempt to increase the adoption of microfluidics in clinical trials. ; Bachmann, T.T. Fu, X.; Wang, Y.; Liu, Y.; Liu, H.; Fu, L.; Wen, J.; Li, J.; Wei, P.; Chen, L. A graphene oxide/gold nanoparticle-based amplification method for SERS immunoassay of cardiac troponin I. Li, F.; Guo, L.; Hu, Y.; Li, Z.; Liu, J.; He, J.; Cui, H. Multiplexed chemiluminescence determination of three acute myocardial infarction biomarkers based on microfluidic paper-based immunodevice dual amplified by multifunctionalized gold nanoparticles. Patients in these areas often do not have enough time or money to receive routine medical testing. ; Lewis, T.; Guijt, R.M. Review: Carbon nanotube for microfluidic lab-on-a-chip application. ; Leung, W.S. Uddin, M.J.; Bhuiyan, N.H.; Shim, J.S. Microfluidic POC devices have better integration. Microfluidic point-of-care devices: New trends and future prospects for ehealth diagnostics. Yan, J.J.; Yang, Q.L. This review details microfluidic POC equipment and its applications. With the continuous combination of related technologies and microfluidic devices, microfluidic detection devices have also been successfully applied with a high specificity and very low detection limit. The Feature Paper can be either an original research article, a substantial novel research study that often involves Screening for Prostatic Carcinoma with Prostate Specific Antigen: Results of the Second Year. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: A prospective study. Huang, X.; Li, Y.; Chen, J.; Liu, J.; Wang, R.; Xu, X.; Yao, J.; Guo, J. Smartphone-based blood lipid data acquisition for cardiovascular disease management in internet of medical things. Then, we introduce the current and future applications of microfluidic POC devices for medical detection of infectious diseases, cardiovascular diseases (CVDs), tumors, and other chronic diseases. These wearable devices can also continuously transmit biological data to the internet in real time, so as to convert this information into clinical knowledge for monitoring the physical condition of patients [, Traditional immune monitoring requires trained personnel and specialized equipment. Du, Y.; Tu, L.; Zhu, P.; Mu, M.; Wang, R.; Yang, P.; Wang, X.; Hu, C.; Ping, R.; Hu, P.; et al. Nurtop, E.; Villarroel, P.; Pastorino, B.; Ninove, L.; Gallian, P. Correction to: Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies. Terry, S.C.; Herman, J.H. ; Sinha, S.; Standeven, J.; Bhamla, M.S. ; Albert, M.A. and Y.C. Expensive professional testing instruments must be placed in research laboratories, and their complex operation requires trained professionals. marketsandmarkets estrela diagnostics disease Rissin, D.M. Lamb, L.E. School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China, Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada, Clinical Research Center, The Affiliated Wuxi Peoples Hospital, Nanjing Medical University, 299 Qingyang Road, Wuxi 214023, China. Bashshur, R.; Doarn, C.R. Vishwanatham, A.; Narendra, C.; Abhishek, S.R. Please let us know what you think of our products and services. Voller, A.; Bartlett, A.; Bidwell, D.E. System integrating a 3D-printed microfluidic chip with a smartphone. Bioprinting is a promising method that can print organ structures to study underlying pathological mechanisms. PDMS, plastic, paper, and 3D-printed devices, Soft lithography or 3D printing technology. Soares, R.R.G. Copyright 2022 Elsevier B.V. or its licensors or contributors. Fabrication of microfluidic systems in poly(dimethylsiloxane). Hyperlipidemia is a common chronic disease that may lead to CVD. Zaman, M.A. Multiplex immunosensor arrays for electrochemical detection of cancer biomarker proteins. ; Celis-Morales, C.A. ; nal, B.; Khademhosseini, A.; Butt, H. Wearables in medicine. Paper microfluidic device for early diagnosis and prognosis of acute myocardial infarction via quantitative multiplex cardiac biomarker detection. Soft lithography for microfluidics: A Review. 212215. ; Sniadecki, N.J. A microfluidic approach for hemoglobin detection in whole blood. ; Zheng, L.; DiazGranados, C.A. droplet microfluidic routing biochip digital paths minimum alternate weight based number algorithm schematic fig diagram biochemical Song, J.; Mauk, M.G. Graham, H.; Chandler, D.J. Kan, C.W. The platform uses reverse-transcription loop-mediated isothermal amplification (RT-LAMP) technology to realize the rapid detection of the Zika virus. ; Piech, T.; Patel, P.P. ; Goldberger, Z.D. This work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare. Alterovitz, G.; Alterovitz, W.L. Mielczarek, W.S. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Over 75% of these deaths occur in underdeveloped areas [, The cardiovascular system consists of three parts: the heart, the blood, and the blood vessels [, In the past decade, biomarkers have been used in various clinical applications, including detecting CVDs and numerous CVD biomarkers have been discovered. A portable paper-based microfluidic platform for multiplexed electrochemical detection of human immunodeficiency virus and hepatitis C virus antibodies in serum. There are different types of microfluidic POC equipment, but in the final analysis, it can meet the low-cost real-time detection of different regional environments.