id customization of the instrume

2022.07.31
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id customization of the instrume

Rapid customization of the instrument would benefit users. Biomicrofluidics, 2020, 14, (5), DOI: 10.1063/5.0012185. Seep Arora, Christine Cheung, Evelyn Yim*, Yi-Chin Toh*, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, 2020, Biomaterials, 234, 119747. Jyothsna joined The Fermart Lab in 2016 as NUS-SUTD PhD fellow. This is achieved by dispensing a fast-curing flexible silicone resin on various substrates to form microchannels. In 2014 he was awarded the worlds most outstanding young researcher in materials science by the Bayer Foundation. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Fluorescence-based assays have long being used to assess cell viability in microfluidic devices. = Protecting Your Internet-Connected Devices From Threats, Twin Gene-Editing System Gives Twice The Efficiency, Space Exploration Educators Conference 2019, Why Renewable Energy Is Essential To Curbing Climate Change, Self-Driving Cars That Recognize Free Space Can Better Detect Objects, Genetics Influences Where People Choose To Live. At the same time, it generated tremendous respect for all the design engineers who used to work in the dark ages of electronics before HDL and EDA. Microfluidic systems for lab-on-a-chip (LoC) and organs-on-a-chip (OoC) applications require precise fluid flow control. Her research interest is in engineering multi-scale tissue models to mimic complex biological interactions during human development and diseases, as well as translating them into scalable platforms for disease modeling and drug testing applications. Candidate under a joint program between SUTD and the National University of Singapore (NUS) under the guidance of Michinao Hashimoto (SUTD) and Yi-Chin Toh (NUS). Seep, Evelyn Yim, Yi-Chin Toh*, Environmental specification of pluripotent stem cell derived endothelial cells towards arterial and venous subtypes,2019, Frontiers in Bioengineering and Biotechnologyhttps://doi.org/10.3389/fbioe.2019.00143. From a 4-bit CPU that clocked a whopping 740 kilohertz, capable of executing 92,000 instructions per second and accessing 4KB of program memory and 640 bytes of RAM to a a chip with up to 16 cores and 24 threads, 5.2 gigahertz turbo frequency, 30MB shared Intel Smart Cache, DDR5 memory and both PCIe 4.0 and 5.0 for the latest storage and high-performance discrete graphics (Intel 12th Gen) Louis Jun Ye Ong, Liang Zhu, Gabriel Jenn Sern Tan,Yi-Chin Toh*, Quantitative Image-Based Cell Viability (QuantICV) Assay for Microfluidic 3D Tissue Culture Applications, 2020,Micromachines, 11 (7): 10.3390/mi11070669. This paper demonstrated that substratestiffness mediated mechanical cues can directly modulate the development of ectodermal MSCs(eMSCs) from a precursor human neural crest stem cell (NCSC) population. Thanks to Mr. Gustavo for designing such a wonderful course. Sahni, G.,Yuan, J.andToh, Y.C. This paper discusses how microfluidic technologies can value add to the different phases of human microbiome research as well as the unique challenges that microfluidics must overcome when working with microbiome-relevant biological materials. 2D And 3D Combo Could Keep Moores Law Going. Cellular responses to a nanofibrous environment, 2006,NanoToday, 1(3): 34-43. Quantitative Image-Based Cell Viability (QuantICV) Assay for Microfluidic 3D Tissue Culture Applications, Bio-mimicking shear stress environments for enhancing mesenchymal stem cell differentiation, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, Targeting downstream subcellular YAP activity as a function of matrix stiness with Verteporn-encapsulated chitosan microsphere attenuates osteoarthritis, Fabrication of Complex 3D Fluidic Networks via Modularized Stereolithography, Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites, Self-Aligning Tetris-Like (TILE) Modular Microfluidic Platform for Mimicking Multi-Organ Interactions, Fabrication of Integrated Microfluidic Devices by Direct Ink Write (DIW) 3D Printing, Environmental specification of pluripotent stem cell derived endothelial cells towards arterial and venous subtypes, Human Pluripotent Stem Cell-derived Neural Crest Cells for Tissue Regeneration and Disease Modeling, Determination of critical shear stress for maturation of human pluripotent stem cell derived endothelial cells towards an arterial subtype, A liver-immune coculture array for predicting systemic drug-induced skin sensitization, A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion, Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling, A 3D Printed Microfluidic Perfusion Device for Multicellular Spheroid Cultures, A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells, Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity, Functionally enhanced human stem cell derived hepatocytes in galactosylated cellulosic sponges for hepatotoxicity testing, Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates, Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules, A method for human teratogen detection by geometrically confined cell differentiation and migration, Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation, A scalable method for aligning 3D micro-tissues in microfluidic chips, Scalable cell alignment on optical media substrates, Mechanical compaction directly modulates the dynamics of bile canaliculi formation, Leveraging on being smallSingapores strategy to catalyze integrative innovations, Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, Advancing Stem Cell Research with microtechnologies: opportunities and challenges, A microfluidic 3D hepatocyte chip for drug toxicity testing, The controlled presentation of TGF-b1 to hepatocytes in a 3D microfludic cell culture system, Microfabricated silicon nitride membranes for hepatocyte sandwich culture, Dendrimer hydrazides asmultivalent transient inter cellular linkers, A gel-free 3D microfluidic cell culture system, Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection, Development of dual-compartment perfusionbioreactor for serial coculture of hepatocytes and stellate cells in poly (lactic-co-glycolic acid)-collagen scaffolds, A Practical Guide to Microfluidic Perfusion Culture of Adherent Mammalian Cells, A novel 3D mammalian cell perfusion-culture system in microfluidic channels. This paper investigates the potential of neural crest derived human ecto-mesenchymal stem cells (eMSCs) for future clinical use in craniofacial regeneration applications and indicates the importance of considering MSC origin when selecting an MSC source for regenerative applications. Development of poly (lactic-co-glycolic acid)-collagen scaffolds for tissue engineering. }. Her thesis focused on understanding the physical and chemical properties of biodegradable polyesters and their applications as protein delivery systems. Development of poly (lactic-co-glycolic acid)-collagen scaffolds for tissue engineering. Later, he moved to the Wyss Institute at Harvard University, where he designed and made Shrilk, a compostable and biocompatible material inspired by the insect cuticle. Toh, Y.C., Yen, J.J.L., Obbard, J.P. and Ting, Y.P., 2003. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Here, we designed a 3D printable micro-peristaltic pump kit as a cost-effective (~50 USD) alternative to current commercial pumps (>1000 USD). Today I came across a new course Assembly Language by Making Games for Atari 2600 nine In this paper, we detail the fabrication and operation of two variations of pumps with different flow rates using the developed kit. A gel-free 3D microfluidic cell culture system, 2008,Biomaterials, 29(22): 3237-3244, Toh, Y.C., Zhang, J., Khong, Y.M., Du, Y., Sun, W. and Yu, H., 2008. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will have a significant impact on business, medicine or culture.. Prior to her research stint at NUS, she completed her Bachelors degree in Biotechnology from SRM University, Chennai. In this paper, we combine hPSC micropatterning and a temporallysequenced induction protocol to specify neuroepithelial (NE) cells in spatial juxtaposition to mesoendoderm cells. 2007,Lab on a Chip, 7(3): 302-309. Michinao Hashimoto is an Associate Professor at Singapore University of Technology and Design leading Soft Fluidics Group. She is passionate about understanding the properties of different types of materials and how they can be applied to the domain of living or biological systems. Terry Ching, Yingying Li, Rahul Karyappa, Akihiro Ohno, Yi-Chin Toh, Michinao Hashimoto, Fabrication of Integrated Microfluidic Devices by Direct Ink Write (DIW) 3D Printing, 2019, Sensors & Actuators B: Chemicalhttps://doi.org/10.1016/j.snb.2019.05.086. Terry Ching, Jyothsna Vasudevan, Hsih Yin Tan, Chwee Teck Lim, Javier Fernandez, Yi-Chin Toh*, Michinao Hashimoto, Highly-customizable 3D-printed peristaltic pump kit, 2021,HardwareX, e00202. Xianzhu Zhang, Dandan Cai, Feifei Zhou, Jie Yu, Xinyu Wu, Dongsheng Yu, Yiwei Zou, Yi Hong, Chunhui Yuan, Yishan Chen, Zongyou Pan, Varitsara Bunpetch, Heng Sun, Chengrui An, Yi-Chin Toh, Hongwei Ouyang, Shufang Zhang, Targeting downstream subcellular YAP activity as a function of matrix stiness with Verteporn-encapsulated chitosan microsphere attenuates osteoarthritis, 2020,Biomaterials, 232: 119724, Terry Ching, Yi-Chin Toh, Michinao Hashimoto, Fabrication of Complex 3D Fluidic Networks via Modularized Stereolithography, 2019, Advanced Engineering Materials, 1901109, https://doi.org/10.1002/adem.201901109. Shrilk is referred, for example, to as one of the materials that will change the future of manufacturing (Scientific American), a Supermaterial (National Geographic), and has been chosen (with graphene) one of the five material that could change the word (The Guardian). Lor Huai Chong, Celine Ng, Huan Li, Edmund Feng Tian, Abhishek Ananthanarayanan, Michael McMillian, Yi-Chin Toh, Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites, 2019,ACS Omega,4, 9, 13902-13912. The pump is powered and controlled by Arduino, an open-source electronics platform. Dendrimer hydrazides asmultivalent transient inter cellular linkers, Biomaterials, 2008, 29 (27): 3693-3702, Ong, S.M., Zhang, C.,Toh, Y.C., Kim, S.H., Foo, H.L., Tan, C.H., van Noort, D., Park, S. and Yu, H., 2008. and Yu, H., 2013. To make microfluidic pumps more accessible to the scientific community, researchers from the Singapore University of Technology and Design (SUTD) Soft Fluidics Lab developed a highly-customizable, 3D-printed peristaltic pump kit, where users from around the world can download the design files, 3D-print and assemble their do-it-yourself (DIY) peristaltic pump (refer to image). Terry Ching received his bachelors degree in Engineering from the Singapore University of Technology and Design (SUTD). Development of dual-compartment perfusionbioreactor for serial coculture of hepatocytes and stellate cells in poly (lactic-co-glycolic acid)-collagen scaffolds,Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2008, 87(1): 154-162. We also discovered that substrate stiffness modulated the differentiation of NCSCs to eMSCs via a Rho-ROCK dependent pathway involving CD44-mediated inhibition of PDGFR signaling. You can also collaborate with Pioneering Minds on patents within various categories of emerging fields like AI, Space Exploration, Nanomaterials, Autonomous Vehicles, DNA Editing, Robotics, IOT, Quantum Computing, Wearables, 3D Printing, Cryptocurrency, Energy Storage, Neurophotonics and other. The peristaltic pump kit exhibited good repeatability in flow rates and functioned for 7 days without any noticeable issues in performance. and Yu, H., 2007. This cost-effective, highly customizable pump kit should find use in lab-on-a-chip, organs-on-a-chip, and point-of-care microfluidic applications. Recently I found a post on Facebook as a meme. Dr Toh is a recipient of the Australia Research Council Future Fellowship, National University of Singapore Research Scholarship, A*STAR Graduate Scholarship and A*STAR International Fellowship. Toh, Y.C., Ng, S., Khong, Y.M., Samper, V. and Yu, H., 2005. Toh, Y.C., Ho, S.T., Zhou, Y., Hutmacher, D.W. and Yu, H., 2005. *,A 3D Printed Microfluidic Perfusion Device for Multicellular Spheroid Cultures, 2017,Biofabrication, Ong, L.J.Y., Chong, L.H., Jin, L., Singh, P.K., Lee, P.S., Yu, H., Ananthanarayanan, A., Leo, H.L.,Toh, Y.C. A microfluidic 3D hepatocyte chip for drug toxicity testing, 2009,Lab on a Chip, 9(14): 2026-2035, Zhang, C., Chia, S.M., Ong, S.M., Zhang, S.,Toh, Y.C., van Noort, D. and Yu, H., 2009. He has been also awarded with theZwick Science Awardfor his studies on Mechanical Testing, and best PhD thesis at the University of Barcelona for studies in the use of biopolymers inMicroelectronicsandBiomedicine. She obtained her B.Eng in Chemical Engineering and Ph.D in Bioengineering from the National University of Singapore in 2001 and 2008 respectively. Choudhury, Y.#, Toh, Y.C.#, Xing, J., Qu, Y., Poh, J., Huan, L., Tan, H.S., Kanesvaran, R., Yu, H. and Tan, M.H., 2017. A scalable method for aligning 3D micro-tissues in microfluidic chips, 2013,Lab on a Chip, 13(20): 4124 4133, Anene-Nzelu, C.G., Choudhury, D., Li, H., Fraiszudeen, A., Peh, K.Y.,Toh, Y.C., Ng, S.H., Leo, H.L. Published by Elsevier Ltd. https://doi.org/10.1016/j.ohx.2021.e00202. To demonstrate the forward compatibility, we developed a flowrate calibration tool that was readily interfaced with the developed pump system. Being Restless and curious, I invested my time and solved it. Tasnim, F., Phan, D., Toh, Y.C. Hsih Yin Tan and Yi-Chin Toh*, What can microfluidics do for microbiome research? It was very interesting and I had learned a lot about old ROM Programming, Sprits design, 6507 CPU chip, etc. His research focuses on novel 3D printing methods to fabricate microfluidics, organs-on-a-chip, and biomimetic vasculature. Kim, L.,Toh, Y.C., Voldman, J. and Yu, H., 2007. Advancing Stem Cell Research with microtechnologies: opportunities and challenges, 2010,Integrative Biology, 2: 305-325, Toh, Y.C., Lim, T.C., Tai, D., Xiao, G., van Noort, D. and Yu, H., 2009. They developed a highly-customizable, 3D-printed peristaltic pump kit.

Javier regularly collaborates with some of the most important international media outlets. Enzyme and Microbial Technology, 2003, 33(5): 569-575. Application of polyelectrolyte complex coacervation to improve the seeding efficiency of bone marrow stromal cells in 3D scaffolds. 2005,Biomaterials,26(19): 41494160. Y.C. Featured in RSCs Chemical Biology, 2007, Issue 4Featured in RSCs Chemical Biology, 2007, Issue 4. By continuing you agree to the use of cookies. Featured in Global Medical Discovery(ISSN 1929-8536),Featured in Global Medical Discovery (ISSN 1929-8536), Jan 2013, Toh, Y.C., Blagovic, K., Yu, H. and Voldman, J., 2011. | How does your Smartphone store data? Currently, she is a postdoctoral fellow of Institute of Health Innovation and Technology in Prof C. T. Lim's group at the National University of Singapore. display: none !important;

Yi-Chin Toh is a Future Fellow and Associate Professor at the Queensland University of Technology. This paper reports a liver-immune coculture array that can mimic liver-mediated bioactivation of parent drugs into reactive metabolites and their subsequent activation of immune cells. Javiers research at SUTD is focused on the broadstudy, development, and application of biological materials in science and technology. and Yu, H., 2008. You will receive a link to create a new password via email. This review aims to provide a framework as well as highlight opportunities to advance pluripotent stem cell endothelial cell differentiation protocols from EC lineage commitment to arterial-venous specification. Different endothelial cell subtypes often exhibit similar morphological response to topographical cues, however, they can demonstrate different phenotypic and functional responses. Semiconductor Technology. Professor Lim is the inaugural NUSS chair Professor at the Department of Biomedical Engineering and Founding Principal Investigator at the Mechanobiology Institute. Download : Download high-res image (220KB)Download : Download full-size image. In 2020, he joined Shrike Zhangs Laboratory at Harvard Medical School as a visiting research trainee, working on light-based 3D bioprinting. Anene-Nzelu, C.G., Peh, K.Y., Fraiszudeen, A., Kuan, Y.H., Ng, S.H.,Toh, Y.C.

Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. After his Ph.D, Javier moved to MIT, where he developed the Micro-Masonry, a technology to assemble artificial organs and recognized as breakthrough in tissue engineering (CNET). Mechanical compaction directly modulates the dynamics of bile canaliculi formation, 2013,Integrative Biology, 5 (2): 390 400. The pump is designed in the form of a kit, allowing end-users to customize the setup. Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, 2011,FASEB Journal, 25: 1208-1217, Toh, Y.C., Blagovi, K. and Voldman, J., 2010. Singapore University of Technology and Design (SUTD), Researchers developed DIY 3D-printed peristaltic pump kits for microfluidics, SHAKTI announces third silicon success with the Arduino-compatible Moushik, How do SSDs Work? A method for human teratogen detection by geometrically confined cell differentiation and migration. This resulted in the formation of a reproducible and highlyorganized NE tissue. This is a collaborative effort with Dr Thomas Willett @ Waterloo University demonstrating the utility of 3D printed soybean-based scaffolds for bone tissue engineering application. Leveraging on being smallSingapores strategy to catalyze integrative innovations, 2011,Lab on a Chip, 11: 1853-1855(Invited article), Toh, Y.C. He and his team have garnered close to 100 research awards and honors including Highly Cited Researcher 2019, Winner of IDTechEx Launchpad 2017, International Precision Medicine Conference Prize 2017, ASEAN Outstanding Engineering Achievement Award and Asian Scientists 100 in 2016, Vladimir K. Zworykin Award in 2015, Universitys Outstanding Researcher Award and Outstanding Innovator Award in 2014, the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) in 2012, Presidents Technology Award in 2011 and the IES Prestigious Engineering Achievement Award in 2010 among others.